Azure Biosystems announces release of new Sapphire™ FL Biomolecular Imager

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Dublin, Calif. – March 1, 2023 –  Azure Biosystems is pleased to announce the release of the Sapphire FL Biomolecular Imager. This groundbreaking new imaging system introduces a patent-pending design for a compatible application list that is almost limitless. Interchangeable and customizable laser and filter modules allow the end user to choose the laser-filter pairs best suited to their research, or even create their own laser-filter pairs as needed.

The new system supports multicolor visible and NIR fluorescence, as well as phosphor imaging. Fluorescence imaging is possible with excitation wavelengths between 365 nm and 850 nm and emission wavelengths between 380 nm and 900 nm, which covers a huge range of fluorescent labels for the ultimate flexibility in experimental design.

Scientist opening Sapphire FL to change out lasers
Changing the optical modules on the new Sapphire FL is simple and easy. Loading a new laser and filter combination into the system is quick and simple.

The introduction of the channel customization makes it an ideal instrument for labs who need 1- or 2-color imaging, while its flexibility will appeal to core labs who need flexibility in imaging size and height and the ability to conduct multi-color (more than 2-color) imaging of their samples. Custom lasers and filters are available upon request so no research will ever be constrained by instrumental limitations.

All of this flexibility comes with the same large imaging area (25 cm x 25 cm) as its precursor, the Sapphire, and upgraded high-resolution imaging abilities down to 5 microns. In addition to flat samples such as gels, membranes, and slides, the Sapphire FL images samples having depth. A new 4-cm clearance above the imaging platform, makes it compatible with petri dishes, multi-well plates, as well as biological samples such as plants, tissues, and small experimental animals. Another new feature is five built-in anesthesia ports for imaging live animals. 

The familiar wide linear dynamic range makes this new instrument a perfect choice for quantitative experiments, such as multicolor Western blots. The Sapphire FL’s Extended Dynamic Range (EDR) function enables capture of 24-bit data for an even more powerful ability to image low- and high-intensity bands in a single image.

An adjustable Z-plane allows collection of image stacks. It also gives control of the focal plane from 1 mm below the glass surface to 6 mm above the surface to capture the ideal image of a thick sample.

The Sapphire FL’s flexibility supports a wide range of applications, including in-gel imaging, Southern and Western blots, membrane arrays, in-cell Westerns, autoradiography, model organism imaging, and so much more. Users can choose to add a Chemiluminescence Module to expand the Sapphire FL’s compatibility to include the ability to image chemiluminescent samples.

Learn more about the Sapphire FL here.

About Azure Biosystems

Azure Biosystems Inc. is an innovative life science platform company that designs, develops and markets state-of-the-art instruments, including the Azure Imaging Systems and the Azure Cielo Real-time PCR system. Azure Biosystems’ experienced team has developed 2nd and 3rd generation imaging systems for the life science market, thus applying their technical and market knowledge in creating innovative industry standard setting platforms.


Lisa Isailovic
(925) 307-7127

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