Azure enters genomics field with launch of Cielo™ for Real-time PCR

Press Releases

Dublin, Calif. – June 1, 2020 – Azure Biosystems, a leading provider of innovative bioanalytical solutions for protein and cell biology, announced today the launch of the Azure Cielo™ Real-time PCR instrument. The Cielo is a 96-well qPCR machine that upholds the brand promise of: high performance, compact design, and intuitive workflow. The Cielo marks first instrument dedicated to the genomics workflow for Azure Biosystems.

The sensitivity and reproducibility of the Cielo comes from its innovative optical design. Previous generations of real-time PCR instruments generally acquired data by whole plate imaging or single well imaging. Whole plate imaging can result in lower excitation efficiency as the light is spread out over all 96 samples, thereby dropping the excitation efficiency required for the actual qPCR reaction. Additionally, non-well regions are also excited, potentially leading to higher background, and interfering with sample signal. Single well detection can slow down scan time, and even with the precise excitation, few pixels are actually scanned for analysis. The Cielo utilizes single well excitation and emission, while simultaneously imaging 16 wells at a time. The powerful light source focused on a small region allows sensitive detection in all channels, with no stray light falling between wells and increasing background. Additionally, over 100,000 pixels are imaged from each well on each scan, providing data that is a true representation of the average signal of the well.

The Azure Cielo will be available in two models, the Azure Cielo 3 and the Azure Cielo 6, for multiplexing 3 or 6 channels respectively. The instrument is controlled by a 10.3” touch screen interface, with intuitive software that makes setting up runs and checking run status easy. The compact instrument can transfer data via USB, ethernet or Wifi. For run setup and data analysis, the system comes with Azure Cielo Manager software which offers a complete workflow solution for real time PCR run setup and analysis.

The Azure Cielo will begin global shipping in June 2020.

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About Azure Biosystems

Azure Biosystems Inc. is an innovative life science platform company that designs, develops and markets state-of-the-art instruments, including Sapphire Biomolecular Imaging Systems, and Azure Imaging Systems. By designing instruments that combine quantitative detection, enhanced flexibility, and streamlined workflows, we enable scientists to quickly and confidently advance their studies using the workflows that work best for them. With an experienced team has decades of experience developing 2nd and 3rd generation imaging systems for the life science market, we create innovative platforms that set the definition of industry standards.

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