New Azure Sapphire FL vs. Cytiva Amersham® Typhoon®

The new Sapphire FL from Azure Biosystems is ahead of other brands like Cytiva and the Amersham Typhoon because it is backed by the most innovative technology on the market. The Sapphire FL does MORE (and does it better). See how innovative technology can improve your gel and Western blot workflow today.

Azure Sapphire FL Biomolecular Imager with lid open

One system for:

  • NIR Fluorescence
  • Visible Fluorescence
  • Phosphor imaging
  • Chemiluminescence imaging*

*available with optional Chemiluminescent Module

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Thinking about buying a new laser scanning imager for your lab?


Azure Sapphire FL

It’s time to consider a new idea, an innovative system with proven results! Instead of taking the easy path and sticking with the same vendor, make the switch to a company that fully supports your research. Azure Biosystems recently launched the new Sapphire FL, which delivers more than the Cytiva Typhoon. The Sapphire FL offers:

Visible Fluorescence ✅

NIR Fluorescence ✅

Phosphor Imaging ✅

Chemiluminescence* ✅

Fluorescence Detectors: APD + PMT

Automatic Z-plane Imaging Tool ✅

Fluorescence imaging area: 25 x 25 cm

Laser diode lifespan: 40,000 hours

Resolution: 5-1000 µm

Non-proprietary Image Formats ✅

Dynamic Range: > 6 logs

What Your Peers are Saying about the Sapphire

"The Sapphire is highly recommended for anyone who routinely uses electrophoresis, cell-based, or slide-based analyses with fluorescent or chemiluminescent detection."

We purchased the Sapphire Imager to replace our obsolete Typhoon Scanner and could not be happier with the performance and ease of use. Equipped with multiple lasers, it is possible to probe for many proteins at high resolution and with great sensitivity. We primarily use the system for western blotting and fluorescent slide scanning and have had clear, publishable results. The software is easy to use and has many practical features. Customer service is amazing – they are always available, informative, and as scientists, they assist with troubleshooting experimental design and optimizing results. 

Sharyn Rossi

It’s Time to Take Control of your applications

Our dedicated Applications Scientists are ready to answer your questions and provide best practices.

Scientist changing optical modules on the new Azure Sapphire FL
Pick the modules that support your research. Changing the optical modules on the new Sapphire FL is simple and easy. The unique mechanism makes selecting lasers to match your dyes finally possible. Easily swap lasers, filters, and/or entire optical modules in under two minutes to suit the needs of your experiment.

READY TO Improve your gel and blot workflows?

As scientists, we like to pride ourselves on objectively evaluating data before coming to any conclusions, and staying open to new ideas if they are better supported by new information. Purchasing a new piece of lab equipment should be no different, especially when it comes to instruments we entrust to make measurements and record data for our critical studies.

The new Sapphire FL offers customizable and user-changeable optical modules, 5–1000 μm resolution scans, a Z-plane range from -1.0 to +6 mm, 5 anesthesia output ports for imaging living animals, chemiluminescence detection through an optional Chemiluminescence Module and much more.

More than Phosphor Imaging

With support of wavelengths between 375 – 900 nm, the Sapphire FL’s patent-pending design enables true dye and application flexibility. This versatility permits research-driven, rather than instrument-dictated, experimental design.

In addition to fluorescence, the Sapphire FL also excels at imaging phosphor screens. The flexibility of the Sapphire FL guarantees you the freedom to confidently choose the best dyes and chemistry for any experiment.

The Sapphire FL Z-plane ranges from -1 mm below to +6 mm above the glass imaging surface, providing the flexibility to image any sample with optimal focus. Additionally, easily create Z-stacks and GIFs to quickly visualize and share data across a range of focal planes.

A 50-micron scan of a flower was taken using an Azure Sapphire FL from 0 to 6 mm with 1 mm adjustments.
50-micron scan of a flower was taken from 0 to 6 mm with 1 mm adjustments.
50-micron scan of the same flower was merged in the Sapphire FL Capture Software to view all areas of focus at once.
50-micron scan of the same flower was merged in the Sapphire FL Capture Software to view all areas of focus at once.

Sapphire FL Applications

Southern blots | Northern blots | Western blots | Multiplex Westerns | Quantitative Westerns | Total Protein Normalization | In-cell Westerns | Agar plates/Clonogenic assays | Multi-well plate imaging | Protein arrays | Microarrays | ELISAs | Immunohistochemistry | Lateral flow immunoassay development | Thin layer chromatography imaging |  Electrophoretic mobility shift assays (EMSA) | 2D DIGE | Densitometry  |  Gel documentation | In-gel imaging | DNA gel imaging | RNA gel imaging  |  Protein gel imaging | Coomassie imaging | Silver-stain imaging |  Fluorescent gel stain imaging | Gel autoradiography | Membrane autoradiography | Tissue section autoradiography | Tissue section imaging | Plant bioluminescence imaging |  Phosphoprotein studies | Glycoprotein assays | Reporter gene assays | GFP expression in model organisms | Small animal imaging

Sapphire™Amersham® Typhoon®
NIR Fluorescence
Visible Fluorescence
Phosphor Imaging
Software-controlled, fine z-axis
Ability to switch between
sequential and simultaneous scanning
True chemiluminescence imaging
using a CCD with the same sensitivity as film
Dynamic Range> 6 logs> 5 logs

Comparing Sapphire FL vs. Cytiva Typhoon

product specs

Available Lasers by system

Table 1. The Azure Sapphire FL Biomolecular Imager offers the greatest variety of excitation wavelengths of the instruments in its class.

Amersham Typhoon™ is a registered trademark of Cytiva. No endorsement is implied by the use of these marks. All rights reserved. The Azure Biosystems logo, Azure Biosystems™ and Azure Sapphire™ are trademarks of Azure Biosystems, Inc.

more reasons to make the change to Sapphire FL

  • Easily swap lasers and filters for expanded dye flexibility
  • Compatible with all third party dyes
  • >6 log dynamic range in a single acquisition without the use of image or data manipulating algorithms, so your raw data is truly raw
  • 5 outlet ports for anesthesia to enable imaging of small animals
  • Complete control of the z-axis and focal plane from -1.0 to +6 mm, at 0.01mm increments for more precise focus and signal to noise ratios
  • Multiplex fluorescence scanning of both visible and NIR wavelengths, phosphor imaging, and the option to add true chemiluminescence imaging
  • Optional Chemiluminescent Module that surpasses film
  • Higher sensitivity for lower limits of detection (femtograms)
  • Broad linear dynamic range for accurate quantitation
  • Ease of use with intuitive control software

Find out what the hype is about.

If you’re ready to see what more really means when it comes to a laser scanning imager for your lab, request a quote- your research will thank you.

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